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Sunday, May 3, 2020 | History

2 edition of Aminophylline dosing in congestive heart failure found in the catalog.

Aminophylline dosing in congestive heart failure

Marshall Tate

Aminophylline dosing in congestive heart failure

  • 119 Want to read
  • 12 Currently reading

Published .
Written in English

    Subjects:
  • Theophylline.

  • Edition Notes

    Statementby Marshall Tate.
    The Physical Object
    Pagination[7], 45 leaves, bound ;
    Number of Pages45
    ID Numbers
    Open LibraryOL15068708M

    Initial dose: mg PO qhr; titrate dose qweeks. Maintenance dose: mg/day PO divided qhr. Dosing considerations. Adjust dose per individual response. Dosage Forms & Strengths. injectable solution. Severe Essential Hypertension. mg/kg/day IM or IV divided in doses. Heart Failure, Afterload Reduction. Recommended initial dose Recommended maintenance dose; Angina pectoris: mg every 12 hours: - 25 mg every 12 hours: Hypertension: mg every 12 hours: - 25 mg every 12 hours: Congestive heart failure: mg every 12 hours: mg every 12 hours. Shahrokh Javaheri, in Heart Failure: A Companion to Braunwald's Heart Disease (Second Edition), Theophylline. Aminophylline and theophylline have long been known to alleviate CSA in premature infants and adults. Open-label studies have demonstrated the efficacy of this drug in the treatment of CSA in patients with heart failure. 3, In a double-blind, randomized, placebo .


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Aminophylline dosing in congestive heart failure by Marshall Tate Download PDF EPUB FB2

FDA recommended for "patients with congestive heart. failure, liver disease" an aminophylline maintenance dose. of mg/kg/hr IBM for the first 12 hours following a. loading dose and mg/kg/hr IBM for a maintenance.

A study was designed to examine the pharmacokinetics of theophylline in a well defined group of congestive heart failure (CHF) patients, without liver disease, and to evaluate the validity of the dosage guidelines recommended by the FDA.

A total of five CHF patients and seven non-CHF patients were entered and : Marshall Tate. Patient with cor pulmonale or congestive heart failure: mg/kg/hr continuous intravenous infusion. Oral: (Patient not receiving aminophylline or theophylline) Loading dose: mg/kg orally once.

Maintenance dose (following loading dose): Otherwise healthy nonsmoking adult: mg/kg/day in divided doses. Do not exceed 1, mg/day. Role of aminophylline in refractory heart failure: a comparison to the vasodilator sodium nitroprusside, the old and the new.

DiBianco R, Rosenfeld SP, Katz RJ, Simpson AG, Aminophylline dosing in congestive heart failure book RD, Singh S. Aminophylline [(theophylline ethylene diamine (TED)] reportedly improved cardiac hemodynamics Aminophylline dosing in congestive heart failure book lowering vascular resistances and increasing by: 2.

Methylxanthines (Includes aminophylline) ↔ renal dysfunction. Severe Potential Hazard, Moderate plausibility. Applies to: Renal Dysfunction The metabolites of theophylline, which are generally undetectable in patients with normal renal function, may accumulate in patients with renal impairment and contribute to the toxicity of theophylline.

Once a serum concentration of 10 to 15 mcg/mL theophylline is achieved by loading dose: 1 mg aminophylline/kg ideal body weight/hour as a constant infusion -Obtain a second serum theophylline concentration about one half-life after starting the infusion; the manufacturer product information should be consulted.

Limit your use of caffeine (for example, tea, coffee, cola) and chocolate. Use with aminophylline may cause nervousness, shakiness, and a fast heartbeat.

Talk with your doctor before you drink alcohol. If you Aminophylline dosing in congestive heart failure book or stop smoking tobacco or marijuana, talk with your doctor. How much drug you take may need to. The table below outlines the maintenance dose for aminophylline.

Patients Maintenance dose in mg/kg For next 12 Aminophylline dosing in congestive heart failure book post loading dose Beyond 12 hours Young adult smokers mg/kg mg/kg Non-smoking adults mg/kg mg/kg Older patients or those with cor pulmonale mg/kg mg/kg Patients with congestive heart failure or hepatic.

Usual Adult Dose for Congestive Heart Failure. IV/IM: Initial dose: 20 to 40 mg IV (slowly over 1 to 2 minutes) or IM once; may repeat with the same dose or increase by 20 mg no sooner than 2 hours after the previous dose until the desired diuretic effect has been obtained/ Age, smoking, congestive heart failure, other diseases and drug interactions all contribute to a change in the metabolism of theophylline.

These factors all necessitate dosage adjustments in order to achieve and maintain therapeutic serum levels and avoid toxicity.

Theophylline choline mg was given as a single oral dose to Aminophylline dosing in congestive heart failure book patients in chronic left ventricular failure due to myocardial dysfunction.

Cardiac output, left ventricular Aminophylline dosing in congestive heart failure book pressure (LVFP) and right atrial pressure (RAP) were measured with a pulmonary artery thermodilution catheter for the following 3 Cited by: 3.

to 3 mg/kg/dose (aminophylline or theophylline) IV or PO every 8 to 12 hours have been used in clinical trials. Acetazolamide was first used in humans as a new diuretic with potential to treat congestive heart failure after it was found to be more potent and safer than sulfanilamide diuretic.

Several case studies in the s that utilized acetazolamide in heart failure patients demonstrated successful decongestive profiles [4,5,6].Cited by: 1. In patients in congestive heart failure, theophylline in the usual dosage caused a significant fall of venous pressure and a shortening of the abnormally prolonged circulation time.

The effect upon the coronary circulation is uncertain. The coronary vasodilation frequently observed may be secondary to myocardial by: 3. Pharmacokinetics. Aminophylline is a stable mixture or combination of theophylline and ethylenediamine; the ethylenediamine confers greater solubility in water.

Theophylline is metabolised in the liver. The plasma-theophylline concentration is increased in heart failure, hepatic impairment, and in viral infections. Hemodynamic Effects of Aminophylline in Heart Failure* JOHN 0.

PARKER, M.D., F.A.C.C., GARFIELD KELLY, M.D., F.A.C.C. and ROXROY 0. WEST, M.D. Kingston, Ontario, Canada pressures ;2 AIINOPHYLLINE (theophylline ethylene dia- rnine) has been in clinical use for many years in the treatment of cardiac failure, but the hemodynamic effects of this agent have not been completely Cited by: mg/kg/hr IV or mg/kg PO (extended release) q12hr to maintain levels mg/L.

Smokers: mg/kg/hr IV for next 12 hours after loading dose, then mg/kg/hr or 5 mg/kg PO. The total daily dosing of aminophylline averaged ± mg/kg/d on day +1 and ± mg/kg/d on day +2, with the difference between days likely being due to bolus dosing being included in average daily dosing on day +1 (Fig.

Fig.1 1 A).Author: Katie Park, Lindsay C. Trout, Cong Xu, Ming Wang, Robert F. Tamburro, E. Scott Halstead. Use in patients NOT currently receiving theophylline preparations. To minimise adverse effects, IV Aminophylline should be administered slowly, at a rate not exceeding 25mg Aminophylline per minute, up to a dose of mg (5mg/kg).

smoker or has congestive heart failure should also be considered when suggesting doses (1). These are not discussed within this Q+A. It is assumed that the patient has been stabilised on the IV aminophylline dose for at least 48 hours (reaching steady state levels) before starting oral therapy (7).

Table 2 summarizes details about the aminophylline treatment and response in each patient. All patients received a maintenance dose of 1 mg/kg orally or intravenously every 12 hours.

Six patients received an initial loading dose of 5 mg/kg. In this guideline, drugs specifically indicated for use in patients with heart failure are referred to as “primary drugs.” Use of these drugs according to the new classification scheme is Cited by: Congestive heart failure or Cor pulmonale (heart condition) or Fever of degrees F or higher for 24 hours or more or Hypothyroidism (underactive thyroid) or Infection, severe (e.g., sepsis) or Kidney disease in infants younger than 3 months of age or Liver disease (e.g., cirrhosis, hepatitis) or Pulmonary edema (lung condition) or.

increased urination, irregular heart rhythms, increased heart rate, and. What is the dosage for aminophylline. Dosing is based on patient's ideal body weight. In adults a loading dose of mg/kg administered intravenously over 30 minutes followed by a continuous maintenance infusion of mg/kg/hr for non- smokers 60 years or younger and 0.

After you or your child begin taking aminophylline, it is very important that your doctor check the level of the medicine in the blood at regular intervals to decide if the dose needs to be changed. Keep all appointments for testing the blood level.

Dosing. The dose. Loop diuretics are used for pulmonary oedema, congestive heart failure, and in renal disease. Thiazides are used less commonly than loop diuretics but are often used in combination with loop diuretics or spironolactone in the management of pulmonary oedema and, in lower doses, for hypertension associated with cardiac disease.

Aminophylline has been used to augment the diuretic action of the thiazides and carbonic anhydrase inhibitors, and to relieve dyspnea, decrease venous filling pressure, and increase cardiac output when used as an adjunct in the treatment of congestive heart failure.

However, use of aminophylline has largely been replaced by more effective. (2, mg sodium and fluid limited to to 2 L per day) Following a low-sodium diet and drinking less fluid can help you feel better and allow your heart failure medicines to work better.

A low-sodium diet may even keep you out of the hospital. It is not an easy diet to follow. You may find eating with heart failure is a bit of a balancing act. Concurrent administration of phenytoin, phenobarbitone, or rifampicin, which increase P activity, increases metabolic breakdown, so that higher doses may be required.

Reduced clearance is found in liver disease, pneumonia, and heart failure, and doses need to be reduced to one-half and plasma levels monitored carefully. Low-dose dopamine or low-dose nesiritide in acute heart failure with renal dysfunction: the ROSE acute heart failure randomized trial.

JAMA. Dec 18;(23) doi: /jama   AK, Churchill PC. Aminophylline ameliorates glycerol induced acute renal failure in rats. Can J Physiol Pharmacol ;61(6) d AS, Clark CE, Mintz GS, Dosa S, Popura JJ, Pichard AD, Satler LF, Harvey M.

Effects of dopamine and aminophylline on contrast induced acute renal failure after coronary angiography in patients. Theophylline is a bronchodilator used in veterinary therapy that is effective in the management of congestive heart failure, asthmatic bronchitis and chronic obstructive pulmonary disease in animals.

Included in the drug classification as smooth muscle relaxant, the medication is active against conditions affecting the respiratory muscles of dogs and cats.

Caution should be used when giving aminophylline to dogs with seizure disorders. Medications used to treat seizures can lessen the effectiveness of this drug. Animals with hypothyroidism, liver or kidney disease or congestive heart failure should use aminophylline with caution as it can cause problems with these conditions.

The oral dosage of aminophylline required for therapeutic “trough” serum theophylline levels was studied in children, 16 months to 19 years old (mean years).

Dosage requirements tended to be higher for children under 10 years, but marked person-to-person variability in the relation of dose to serum level was seen at all by: 9.

dose 5mg / kg aminophylline IV (max mg) Monitoring Heart rate and blood pressure monitoring should be recorded every hour for the first four hours Liver impairment, congestive heart failure, severe pulmonary obstruction, smoker. Interacting medicines e.g. antibacterials (azithromycin, ciprofloxacin, clarithromycin, File Size: 40KB.

Knowledge acquired of the kinetic disposition and effects of theophylline over the past 8 years has increased the clinical utility of the drug in the treatment of cardiorespiratory disorders. Although the anhydrous theophylline content varies greatly between products, there is similar excellent oral bioavailability.

An average 96% (range 75 to %) of an uncoated theophylline tablet is Cited by:   In patients with congestive heart failure or liver disease, haemodialysis may increase theophylline clearance by as much as 2-fold.

Charcoal haemoperfusion should be considered if: Ileus/ intestinal obstruction prevents administration of multiple dose activated hepatic disease: mg/kg/hour beyond 12 hours).

An year-old patient with congestive heart failure has been sent to a cardiologist who prescribes digoxin (Lanoxin) mg PO every morning. The pharmacy dispenses pills that contain mg of Lanoxin. How many pills should the nurse teach the patient to take every morning.

A) 2: B) C) 1: D) Ans: D. Feedback. Heart failure and fluid build up in the body (congestive heart failure or CHF). Some early research shows that taking creatine daily for days improves muscle strength and endurance but does.

Peter J. Barnes, in Asthma and COPD (Second Edition), Acute exacerbations. Intravenous aminophylline has been used in the management of acute severe asthma for over 50 years, but this use has been questioned in view of the risk of adverse effects compared with nebulized β patients with acute asthma, intravenous aminophylline is less effective than nebulized β 2-agonists.

Theophylline is a pdf used by veterinarians to control several illnesses including congestive heart failure and asthmatic bronchitis in pets. The medicine works by relaxing the smooth muscle surrounding the windpipe leading to easier breathing for animals suffering asthmatic reactions.

Theophylline dosage for dogs.Amrinone, download pdf known as inamrinone, and sold as Inocor, is a pyridine phosphodiesterase 3 inhibitor. It is a drug that may improve the prognosis in patients with congestive heart failure.

Amrinone has been shown to increase the contractions initiated in the heart by high gain calcium induced calcium release (CICR). The positive inotropic effect of amrinone is mediated by the selective Legal status: US: ℞-only.Theophylline is used off label to treat cough ebook by bronchoconstriction.

It is given by mouth in the form ebook a tablet or liquid, or in hospital as an injection. The most common side effects include stomach upset and excitement.

It should be used with caution in pets with abnormal heart rhythms, seizures, stomach ulcers, hyperthyroidism, kidney, liver, or heart disease, severely high blood.